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pentobarbital will lower the level or effect of nisoldipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital will minimize the level or effect of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a sensitive CYP3A4 substrate. Coadministration